Well I'll put it this way, I use a 250GB WD mypassport white drive. I've owned it since sometime in 2007 (well before I purchased my Wii console). It's traveled with me on and off multiple cruise ships (used to work out there), been through any number of flights, seen tons of usage before it ever touched a Wii.
Now that it sits comfortably on my stand here at home, it's been yanked from the Wii and back and forth to my computer so many times I've lost count, and had terabytes and terabytes of data pass through it over the years. Works as good as the day I bought it.