Yes or no: Software update on hardmodded Wii? I don't understand this at all.....

I'm really sorry for posting this here but I was wondering if someone could just tell me yes or no to whether I should do a system update? The wii is asking me to do so or else I won't be able to play a game of mine. It also said that updating could cause the wii to become unusable if I had modified it before. I have a Wiikey 2 in the Wii... Can I update? I would REALLY like to play this game.. Thanks!!

You should Introduce yourself first. And nobody here advocates doing an official System Update. For example, updating your Wii to 4.3 will kill the Wiikey's ability to play out of region games. You can do a softmod (which will allow for Priiloader to block those pesky update prompts) on a hardmodded Wii. Look here.