I followed this guide HOWTO: Setup a System Menu 4.2 Wii for playing backups of commercial games with uLoader Ade's Softmodding Wii blog
and Im currently running uLoader. I want to try USB Loader GX. Am I ok to run USB Loader GX or do I need to change/install anything?
maybe you should ask whoever wrote the guide?
Or find the guide on wiihacks.....