Yes to both questions. You can run it from your HDD and save all associated files such as images there. No need for an SD in this case.
Can i run gx loader for a usb hard drive or does it have to run from sd card?
If so can i save my cover img to the hard drive.
Some one help Cheers
As i say iam new at all this can you point me in the right directions in the guide thanks
Can you that would be nice
Interesting you ask about softmodding in a HARDMOD section. I would suggest you post/look elsewhere on the site like the Recommended Guides section.