Alright here's my issue; I have a 320 GB Western Digital Passport HDD from 2009, currently using it with WiiFlow 2.2 & was a FAT32 from the start. It has full compatibility on that list of external HDDs here. When I'm playing a game it will, after some time & it ALWAYS will happen, stop loading so I have to unplug & reconnect the USB cable (power source is USB). I wouldn't care about this at all since the TV & Wii are right next to me but this happens almost every 15-20 minutes.

This is the same HDD I use with my laptop & I never had any problems with it, guessing it's probably a spin-down option I'm probably overlooking but I honestly checked everywhere & googled my ass off to find a solution without results.