Restoring a NAND on Bootmii/IOS is a first class ticket on the train to bricksville. All aboard!
Seriously don't do it, unless you have the value of one Wii in disposable cash that you don't mind spending of course.
Do you get an error message when you try running the Disc? How old is your Wii? What System Menu are you running? Do Retail games work ok through Neogamma?