Yes, after you successfully softmod your Wii (http://www.wiihacks.com/recommended-...d-any-wii.html), download and install USB Loader GX and WBFS Manager (links are in the tutorial).
Among the least troublesome to install of HDDs are the Western Digital externally powered HDD. Plug your HDD into the bottom or left Wii USB (depending on its position). This is a site with global membership so recommendations for specific purchases is difficult. You can also check for USB HDD compatibility at ·USB Devices Compatibility List - WikiTemp