Most of the newer games requires the Anti 002 fix to be set to the On position in GX. If you get the 002 error then you can be pretty sure you need to swap that option. Also ensure you have installed a reasonably up to date cIOS for your USB HDD, most go with cIOS38 rev 13 or 12 at the moment.
The 3 wads they are talking about are ios38 ios53 and ios55
http://www.wiihacks.com/homebrew-dow...3-55-a-17.html This tutorial was written some time ago but the IOS are required for most of the newer crop of games. If you don't have them then the game will just black screen when run through USB HDD.
Not sure about the grinding noise, sounds nasty though.