This is a recent issue. I haven't used the USB drive to play backups on my Wii in a few weeks, but at that time I had no issue with it. I recently ripped a new game and attempted to play it, and now the USB drive(Iomega Select 320GB) isn't being recognized by the Wii. The USB drive is also making a beeping sound every second when connected to the Wii, but not when connected to the PC. I have no idea what's causing this issue, and the only thing I've changed on the USB drive is adding the new game, Dragon Quest Swords. Would gladly give any additional information as needed.