Try an eSATA to USB 2.0 converter???
I have the WD5000H1CS (MyBook Home 500GB) also have a similar problem. The loader works fine and shows the backup games but they will not load, the drive seems to hang momentarily and the loader shows a black screen.
I believe this is because these drives go into sleep mode if the USB connection pauses momentarily. It is not possible to disable this function, I have googled and read the WD help pages etc.
I will buy an eSATA to USB 2.0 converter and see if this works - another user reported this as a fix for the WD MyBook Studio 500GB: <http://wiki.gbatemp.net/wiki/index.php?title=USB_Devices_Compatibility_List>