I've also seen other users with the same problem. Where their keyboard will stop sync'ing after about 4-5 hours of play. Additionally, they have solved their problem with downloading the right cIOS (usually 223 v4 37/38). Additionally, that solved their microphone issue too. That isn't working for me, though.
I think I just do not have the right combination of cIOS's or IOS's.
PS: I changed it to instruments a few seconds after posting guitar. That was an accident.
"Macs are the Perfect Computers," said the Perfect Idiot.
If the game is run without updating from the disc, then the game is using IOS's that I currently have on my Wii, right? If my controller is no longer sync'ing properly, and my microphone is unrecognised, then the problem logically should be with the IOS's. Especially since the microphone works correctly with Rock Band 2. Also, the Harmonix website states that this microphone is compatible with Rock Band 3.
And also, the 103-button Pro Guitar is designed for Rock Band 3, and Rock Band 3 only. No other game.