I replaced dvd drive and now get error 1101 in neogamma. I am a newbie. Do I have to do the softmodd thing again? Original games work fine.
if you replaced it, to one with a D3-v2 or D4 chip on it you won't be able to read any burned disk with that drive. if you have not updated recently (what you shouldn't anyways) and lost your softmod due to that. it is just your drive which isn't capable of running backups.
you'll have to switch to a usb loading route (link below to Fat32 loading guide). you can read your burned discs on your pc and save them as .iso (with your favorite programm, like Imgburn) and drop them on a external harddrive using a gamemanager (all in the guide), your retail discs can be installed to hdd using a backup loader like cfg usbloader or wiiflow or similar.