Which game is it? It could easily be because of the drive speed issues with DriveKey...
yes i noticed static/stutering audio with warioland shake it and super mario galaxy in the cut scenes I put it to the 3x speed as all other games are fine and the game play is fine just the cut scenes wich is a pain but you get that
Actually, it now seems that the choppy video issue is not related to the reduced drive speed as such, but rather to the fundamental way these new solderless ribbon chips work (on-the-fly patching of data passing on the bus).
Check out this thread at the WiiNewz forum (and in particular this post).